The current MHSAA state record holder in the 100, 200 and 500 freestyle, Comerford was part of another American gold medal group, swimming the second leg of the US women's 800 relay team, which defeated runner-up China by more than one second.
Dressel now has six gold medals in the championships, putting him in position to tie Phelps' record of seven golds at the 2007 worlds in Melbourne, Australia.
"Two more laps to go", Dressel said with a smile. "You have to enjoy the moment and refocus very quickly".
"Man, that was a lot of fun", the 20-year-old Floridian said.
Brazil's Bruno Fratus took silver, 0.12 seconds back, with Ben Proud of Britain snatching bronze. "I'll give myself 30 minutes tonight to, I guess, let it sink in a bit, then it's time to refocus for that relay tomorrow".
He never trailed and delivered two lengths of sizzling pace in 49.86 seconds. That's only.04 off of Michael Phelps' World Record set during the technical suits era.
"I think I only had to run twice", Dressel said with a smile. Schooling's time yesterday was almost half a second slower than his Olympic record of 50.39sec, but he still remains the only Singaporean to win a medal at the World Championships.
At the Fina World Championships in Budapest, Hungary, early this morning (Singapore time) in Budapest, Hungary, the 22-year-old clocked 50.83 seconds to finish joint-third with Briton James Guy in the 100m butterfly final.
Dressel secured his record-equaling feat as the United States won gold in the men's 4x100 meters medley relay, in which he swam the butterfly leg.
He also helped two American relay squads to world records.
SINGAPORE swim star Joseph Schooling eased into the semi-finals of his main event - the 100m butterfly - at the World Championships in Hungary but compatriot Quah Zheng Wen missed out again.
It's been a show-stealing performance for Dressel; Katie Ledecky was the talk of the games heading in.
Hopes had rested heavily on Seebohm with Australia on the cusp of finishing without a world title for the first time in 31 years.
Home-crowd favourite Katinka Hosszu can win her second individual medley title of these championships in the women's 400m final. Kathleen Baker of the US took bronze. Lochte missed out on a chance to qualify for this USA team because of a suspension for his embarrassing antics at last summer's Olympics.
Dressel led off the mixed free relay with a blistering time of 47.22 for the first 100 - even more remarkable given what he'd already been through - and his three teammates - Nathan Adrian, Mallory Comerford and Simone Manuel - took it from there. The Netherlands had to settle for silver in 3:21.81 (also under the former WR), while Canada got the bronze in 3:23.55.